It has been reported that α‐CGRP KO mice have increased activity of the circulating angiotensin‐renin system, and suggested that increased activity of the circulating angiotensin‐renin system might contribute in the further increase in cardiac hypertrophy in TAC α‐CGRP KO mice (Li et al. 2013; Li et al. 2004). Here, REN is linked to cardiac hypertrophy.