Moreover, our study also revealed that the down‐regulation of miR‐27a and up‐regulation of BTG2 resulted in the inhibition of PC cell proliferation, migration, invasion and angiogenesis and enhancement of cell apoptosis, corresponding to diminished levels of MVD as well as angiogenesis growth factor (VEGF and VEGFR) and invasion‐related factors (MMP‐2 and MMP‐9). The gene discussed is MMP2; the disease is pachyonychia congenita.