The ROC curve defined an optimal threshold to predict the recurrence risk of stage II CRC, and the AUC values of the ROC for ZNF561, WFS1, SLC2A1, MFI2, and PTGR1 were 0.7404, 0.7283, 0.6238, 0.6738, and 0.7454, respectively (Figure 2A). The gene discussed is WFS1; the disease is colorectal carcinoma.