VEGFA and neoplasm: Among the mechanisms involved in the above biological processes, oxygen binding,45 iron ion binding,45 heme binding, oxygen transporter activity, oxygen transport, the hemoglobin complex, epidermis development, and the GPCR signaling pathway,46 which were highlighted in the results of the GO functional annotation, are crucial in tumor development; therefore, targeting HIF, VEGF, iron ion binding, and GPCR may be good options for preventing the recurrence of stage II CRC.