CYP19A1 and colorectal carcinoma: Many researchers suggest that polymorphisms in CYP19A1 are related to CRC risk and may be influenced by estrogen through an inflammation‐related mechanism.60, 61 The main function of the TF protein is to transport iron from the intestine, reticuloendothelial system, and liver parenchymal cells to all proliferating cells in the body.