Hepatic insulin sensitivity, as assessed by hyperinsulinemic euglycemic clamp, was markedly improved in Park2 KO mice; whereas hyperinsulinemia produced only a 40% reduction in hepatic glucose production in HFD‐fed WT mice, hepatic glucose production was almost completely suppressed (~97%) by insulin in HFD‐fed Park2 KO mice (Costa et al., 2016). This evidence concerns the gene PRKN and hyperinsulinism.