Using a liver lipidomics approach, Montgomery and colleagues measured ceramide species in five commonly studied mouse strains and found that reductions in very‐long‐chain species of C22 or greater, as well as expression of the enzyme that catalyzes their synthesis, ceramide synthase 2 (Cers2), occurred in strains susceptible to diet‐induced insulin resistance (Montgomery et al., 2016). This evidence concerns the gene CERS2 and Insulin resistance.