TNFα and IL6, which are both positively associated with insulin resistance (Hotamisligil, Shargill, & Spiegelman, 1993; Pickup, Mattock, Chusney, & Burt, 1997), were increased in plasma of HFD‐fed Park2 KO mice, inconsistent with the observed phenotype with regards to insulin sensitivity. This evidence concerns the gene PRKN and Insulin resistance.