This is an intriguing hypothesis given Park2's role in Parkinson's disease where Park2 mutations give rise to loss of dopaminergic neurons in the central nervous system, begging the question as to whether similar changes in dopamine or other monoamine producing neurons in the enteric nervous system occur in Park2 KO mice during HFD feeding and thus alter intestinal motility. The gene discussed is PRKN; the disease is Parkinson disease.