CXCL8 and irritant dermatitis: We also found that LCZ inhibited the production of IL‐8, a neutrophil chemotactic factor, from epidermal keratinocytes.19 Therefore, to characterise the anti‐inflammatory effect of LCZ, we investigated whether LCZ affects the production of the neutrophil chemotactic factor and neutrophilic infiltration to the skin in TPA‐induced irritant dermatitis in mice and compared its inhibitory potency with that of other antifungal agents.