TLR4 and Alzheimer disease: For instance, the uptake of α‐synuclein by microglia has been shown to depend at least in part on TLR4 in models of α‐synucleinopathies.45, 46 This receptor is also responsible for the α‐synuclein‐induced proinflammatory response in astrocytes47 and triggers the amyloid‐β‐induced activation of microglia in AD models.48 As such, it is not unexpected that TLR4 is also involved in the inflammatory response in HD.