Human TNFAIP8 gene encodes eight transcript variants/isoforms, whereas only five protein variants reported so far [10] and TNFAIP8 variant two predominantly expressed in prostate, breast, liver, lung cancer cells, and acute monocytic leukemia derived THP1 cells compared to other variants [10,33]. The gene discussed is TNFAIP8; the disease is acute monocytic leukemia.