In non–small cell lung carcinomas (NSCLC), TNFAIP8 knockdown inhibits EGF and IGF-1 stimulated migration in NSCLC cells by decreasing EGFR levels and by increasing sorting nexin 1 (SNX1), a key regulator of the EGFR trafficking protein [37]. The gene discussed is IGF1; the disease is non-small cell lung carcinoma.