Infection of human mammary tumor cells or canine- derived adenofibrosarcoma cells with canine distemper virus decreased cell proliferation, and induced apoptosis/necrosis and mitochondrial membrane depolarization by increasing expression of TNFAIP8 and CDVM gene expression, suggesting that TNFAIP8 can induce cell death in human mammary tumor cells infected with canine distemper virus [44]. The gene discussed is TNFAIP8; the disease is infection.