Although in AML no major differences between the transcriptomes of KMT2A-rearranged RAS wild-type and KMT2A-rearranged RAS-mutant cells have been found, kinome, proteome profiling, and chemical analyses revealed that the responses of these cells to MEK inhibitors were distinct, suggesting that MEK inhibitors could be effective.36,104. Here, MAP2K7 is linked to acute myeloid leukemia.