PTPN11 and acute myeloid leukemia: Liu et al demonstrated the preclinical therapeutic efficacy of mTOR inhibitor Rapamycin in the mouse model of Ptpn11 mutation-induced MPN and also in PTPN11 mutation-positive JMML patient cells.108 Likewise Parkin et al showed that AML blasts that do not express NF1 display differential sensitivity to in vitro treatment with Rapamycin.64