20,23,24 In the study of Tamai et al, mice developed lymphoma/ALL significantly earlier than the transgenic mice carrying KMT2A-AFF1 alone (median survival 5.5 months vs 12 months), suggesting that KRAS mutations contributes to the early onset of ALL driven by KMT2A-AFF1 (Table 1).72 Here, AFF1 is linked to acute lymphoblastic leukemia.