Neither ferritin nor CRP, nor other biochemical parameters like LDH, AST, ALT, BUN, and creatinine were found to predict the severity of CRS and neurotoxicity.16,64 Recently, elevated levels (≥1343.5 pg/ml) of monocyte chemoattractant protein-1a (MCP-1) in serum of B-ALL, NHL and CLL patients, combined with the presence of fever ≥38.9°C within 36 hours of CAR T cell infusion has shown the capacity of identify patients who develop grade ≥4 CRS with 100% of sensitivity and 95% of specificity.23 The gene discussed is GPT; the disease is congenital rubella syndrome.