KMT2A were found to be rearranged in 79 AML (21%) with 13 different partners among which MLLT3 was by far the most common (n = 36, 46% of KMT2A-rearranged AML) followed by MLLT10 (n = 13, 16%), ELL (n = 6, 8%), MLLT1 (n = 5, 6%), and MLLT4 (n = 5, 6%). This evidence concerns the gene KMT2A and acute myeloid leukemia.