KLK3 and cancer: In relation to prognosis, two studies concluded that the fact of requiring a palliative TURP is an independent adverse prognostic factor, thus proposing a more active and careful treatment [11-12]. Conversely, a recently published study of metastatic PCa patients found that performing palliative TURP in addition to administering ADT, could significantly improve cancer-specific survival (CSS) compared with patients who only received ADT, when PSA ≥65 ng/ml, GS ≥8, and bone metastases ≤5 [13].