NOD2 and Crohn disease: Crohn’s disease has no known cure, with patients requiring at least one single surgical resection [5]. The precise pathogenesis of Crohn’s disease remains unknown; however, research suggests a variety of environmental and genetic factors associated with increased risks of Crohn’s disease [6]. This article will discuss the genetic relationship between Crohn’s disease, more specifically, the genetic relationship between Crohn’s disease and the nucleotide-binding oligomerization domain-containing 2 (NOD2) gene.