Further recurrent genetic lesions in AML relevant for this work include lysine methyl transferase 2A (KMT2A; previously known asMLL) fusion genes, partial tandem duplications withinKMT2A (KMT2A-PTD), and fusion genes between promyelocytic leukemia and retinoic acid receptor alpha (PML-RARA). The gene discussed is RARA; the disease is acute myeloid leukemia.