Our results were supported by the data in Human Protein Atlas database that higher expression of SERPINE1 is associated with lower probability of survival in multiple cancers: urothelial cancer, stomach cancer, lung cancer, head and neck cancer, colorectal cancer and cervical cancer, demonstrating that SERPINE1 is a high confident protein biomarker (https://www.proteinatlas.org/ENSG00000106366-SERPINE1/pathology). This evidence concerns the gene SERPINE1 and colorectal cancer.