To minimize the confounding variable of mistakenly attributing TPO-RA induced TFR, when in fact it could be a consequence of the natural course of the underlying disease, we analyzed the subset of 82 patients with chronic ITP (median time from diagnosis of ITP to therapy with TPO-RA of 5.5 years; 1.1–50.3 years). Here, TPO is linked to autoimmune thrombocytopenic purpura.