When the TPO-RA was started, all patients were reported to have sustained complete remission of previous neoplasias (1 colon carcinoma; 1 Burkitt lymphoma; 1 bladder cancer; 1 breast cancer; 1 patient with history of thyroid, breast and ovarian tumors) and none of them was receiving any cancer-specific therapies. The gene discussed is TPO; the disease is urinary bladder carcinoma.