However, when patients were dichotomized according to age, just in those over 65 years experiencing VE on TPO-RA (8 out of 54) a history of previous neoplasia was associated with VE (50% vs. 2.2%, P < 0.001), whereas only in younger patients with VE during TPO-RA therapy (7 out of 67), previous splenectomy was related to those incidents (100% vs. 33%, P = 0.001). The gene discussed is TPO; the disease is neoplasm.