Compared with rNiVM-wild-type (wt) infection, cells infected with this rNiVM-PG121E increased early ISG production, however not increased production of IFN-β, Interferon Gamma-Induced Protein 10 (IP-10), or Regulated on Activation Normal T Cell Expressed and Secreted (RANTES), thus suggesting that production of IFN and, subsequently, the role of the STAT1-binding domain might have minimal impact in NiV infection. The gene discussed is STAT1; the disease is infection.