Finally, in order to explore the hypothesis proposed by Yan and Stern, we evaluate the effect of the presence of two different Aβ fragments, Aβ1–40 and Aβ1–42 (exhibiting different oligomerization dispositions) on the interaction between 17β-HSD10 and cypD to enable deeper understanding of processes taking places during the early stages of AD. This evidence concerns the gene HSD17B10 and Alzheimer disease.