Enrichment analysis (Fig. 3b, Supplementary Tables 12–16) suggested some processes underlying or related to one or more echocardiographic traits such as lymphocyte activity, cardiomyopathy, left ventricular hypertrophy or oxidative stress response Interestingly, enrichment analysis also suggested an over-representation of genes differentially expressed in AD samples versus control as well as genes involved in tau, presenilin and amyloid biology (APH1B, KLC3, KLC4, MAPK4, MAPK13;MAPK14, PPP2R5D, RBPJ, TCF7L1). This evidence concerns the gene MAPK4 and Alzheimer disease.