We estimated the clonality of BRAF variants in 22 (3 V600, 19 non-V600), 44 (33 V600; 11 non-V600), and 187 (156 V600, 21 non-V600) lung adenocarcinoma (LUAD), colorectal adenocarcinoma (COAD), and melanoma skin cancer (SKCM) tumors, respectively. The gene discussed is BRAF; the disease is colon adenocarcinoma.