As the IL2rα and PDCD1 loci can be efficiently repurposed to secrete IL-12P70 in a controlled and tumor-dependent manner in vitro, we tested whether the IL-12P70 secreting TRACCAR T cells could transiently and locally deliver IL-12P70 to an engrafted tumor in a xenogenic mouse model. This evidence concerns the gene PDCD1 and neoplasm.