CD22 and neoplasm: IL-12P70 secretion was significantly lower in the CD22(−) right tumor site than in the CD22(+) left tumor site (Fig. 5c, Wilcoxon-Mann-Whitney test, p = 0.018 and 0.03 for TRACCAR_CD25IL12 and TRACCAR_ΔPD1IL12, respectively), suggesting that IL-12P70 can be conditionally and locally delivered to a specific tumor site in vivo by TRACCAR T cells.