In accordance with the polysome profiling data, expression of the Saccharomyces cerevisiae NADH dehydrogenase (ETC complex I) NDI135 only partially rescued CR-31-induced suppression of oxidative phosphorylation in PDA cells (Supplementary Fig. 7g), indicating that CR-31 impacts multiple complexes of the ETC (Fig. 4a). Here, ENSG00000251605 is linked to Patent ductus arteriosus.