Indeed, Cel and Li exhibit either anti-inflammatory and antioxidant activities58,59, which could be of interest for BD, as increased levels of inflammation markers (e.g., interleukin (IL)-1β, IL-6, TNF-α, and soluble receptors for IL-2 and TNF) were detected in the serum of bipolar patients60. This evidence concerns the gene IL2 and Behcet disease.