Results revealed that low and moderate inhibition of SPHK1 was capable enough to partly rescue the proliferative ability of indicated cell lines, and CRC cells with POTEE overexpression was more sensitive to SPHK1 knockdown for significantly severer inhibition of cell viability than their negative controls, and the cell growth was extremely suppressed after extensive SPHK1 knockdown (Fig. 4h, i; Supplementary Fig. 4d, e). Here, POTEE is linked to colorectal carcinoma.