AKT1 and Insulin resistance: However, in cells transfected with DYRK1A, moderate insulin responsiveness was observed with increased levels of Ser-473 AKT phosphorylation (288.5 ± 4.0% of control, p < 0.0001), indicating DYRK1A ameliorate insulin resistance (Fig. 6, A and C, lane 8 versus 7).