HMGN3 and Huntington disease: Thus, the observed HMGN3 upregulation in HD NPCs and depletion in HD astrocytes (Additional file 1: Figure S9m) is consistent with our previous findings of other astrocyte-specific genes during HD differentiation (Additional file 1: Figure S2c, d) and provides evidence that premature initiation and incomplete terminal differentiation occurs during HD astrogenesis.