MAPT and Alzheimer disease: In a pilot experiment in an in vivo seeding model in rTg4510 mice, we found that when injected in the CA1 hippocampus of 2-month old rTg4510, both recombinant pre-formed fibrils made of full-length Tau and AD brain extract induced robust AT100-positive Tau pathology in the ipsilateral CA1, while Tau256–368 aggregates did not (data not shown).