Overall, these data indicate that i) N368-cleaved Tau is rather abundant in the soluble extracts of human hippocampus and cerebellum; ii) its levels are comparable in the hippocampus of AD and controls; iii) in AD, N368-cleaved Tau levels do not differ in brain areas bearing Tau pathology, such as hippocampus, compared to cerebellum, which is typically devoid of AD pathology. Here, MAPT is linked to Alzheimer disease.