Interestingly, in the case of RCC, the same pattern as in lung cancer was observed—poorly differentiated tumours or poorly differentiated parts of tumours were lacking a BRM subunit, while more differentiated areas showed BRM expression [72, 74] suggesting that alterations of SMARCA2 gene occur during de-differentiation of ccRCC. The gene discussed is SMARCA2; the disease is nonpapillary renal cell carcinoma.