Analyses of NMSC patient samples, specifically squamous cell carcinoma (SCC) and basal cell carcinoma (BCC) with comparison to benign precancerous lesions—actinic keratosis (AK), which is claimed to be a progenitor for SCC and BCC development, and normal skin showed that the transcript level of SMARCA2 gene decreased in SCC cells. The gene discussed is SMARCA2; the disease is skin basal cell carcinoma.