In humans, BRG1 ATPase may be present in both SWI/SNF CRC classes—BAF (BRM or BRG1-associated factors) and PBAF (polybromo BRG1-associated factors), while BRM has been found in BAF class of SWI/SNF complexes only and is the so-called signature subunit of this complex class. The gene discussed is SMARCA2; the disease is colorectal carcinoma.