CCNE2 and cancer: BRM-containing SWI/SNF CRCs regulate expression of a large number of genes involved in carcinogenesis including (i) epithelial–mesenchymal transition genes, e.g. CDH2 (N-cadherin) and SNAI1; (ii) cell cycle genes, e.g. CCND1 (cyclin D1), CCNE2 (cyclin E2), CDK4 and CDK6 (cyclin kinases), (iii) metabolic genes, e.g. GAPDH, ALDOA and LDHA; (iv) cancer suppressor genes and oncogenes, e.g. BRCA1, PTEN, AKT1, HRAS and KRAS. Importantly, BRM also regulates expression of self-encoding SMARCA2 gene and other SWI/SNF subunits [40].