Notably, cell proliferation (Additional file 10: Figure S6F), cell migration (Additional file 10: Figure S6G-H) and colony formation (Additional file 10: Figure S6I-J) were significantly inhibited and apoptosis was increased (Additional file 10: Figure S6K) in ocular melanoma cells upon HINT2 overexpression. The gene discussed is HINT2; the disease is ocular melanoma.