Because tumor cells present decreased m6A modifications, we next inhibited the expression of the demethylase ALKBH5. CRISPR/Cas9 is utilized to delete ALKBH5 in OCM1 and CRMM1 cells (Additional file 6: Figure S3A), and m6A methylation increases significantly when ALKBH5 is knocked down (Additional file 6: Figure S3B). The gene discussed is MBD2; the disease is neoplasm.