SOX2 and glioblastoma: For example, Somasundaram et al. found that METTL3 acts as an oncogene that promotes tumorigenesis, glioblastoma stem cell maintenance, and radio resistance by regulating SRY-Box 2 (SOX2) [50], whereas Shi et al. reported opposite effects, including inhibition of tumorigenesis and glioblastoma stem cell self-renewal/ proliferation via regulation of ADAM metallopeptidase domain 19 (ADAM19) [43].