HINT2 and neoplasm: We thus tested the tumor suppression role of HINT2 by overexpressing HINT2. In the HINT2-overexpressing group (Fig. 5b, Group B) compared with the empty vector group (Fig. 5b, Group A), we found that tumor volume was persistently reduced (p < 0.01), meeting the changes created by increased global m6A modification (Fig. 5b, Group C).