ASPS is characterised by the pathognomonic unbalanced, non-reciprocal translocation t(X;17)(p11:q25), fusing the alveolar soft part sarcoma chromosome region candidate 1 (ASPSCR1) gene on chromosome 17 to the transcription factor binding to IGHM enhancer 3 (TFE3) gene on the X chromosome (129). Here, TFE3 is linked to alveolar soft part sarcoma.