Furthermore in paediatric osteosarcoma, single-nucleotide variants exhibited kataegis, a pattern of localized hypermutation, with recurrent mutations most frequently observed in the tumour protein p53 (TP53) gene, and also in retinoblastoma protein-1 (RB1), alpha thalassemia/mental retardation syndrome X-linked chromatin remodeler (ATRX), and discs large MAGUK scaffold protein-2 (DLG2) (27). Here, DLG2 is linked to alpha thalassemia spectrum.