CCL22 and arthritic joint disease: In keeping with the anti-inflammatory role of Bregs, we found that the Th2-attracting chemokines Ccl17 and Ccl22 (Imai et al., 1999, Nakayama et al., 2004), and the chemokine receptor Cxcr3, important for the trafficking of lymphocytes to the synovium in arthritis (Mohan and Issekutz, 2007), were upregulated in IL-10eGFP+CD19+CD21hiCD24hiBregs compared with IL-10eGFP−B cell subsets (Figures 1E–1G).