IL10 and Autoimmunity: This sorting strategy was chosen to capture the majority of described Breg subsets, including IL-10+T2-MZP, IL-10+MZ, and IL-10+CD1dhiCD5+, which have been shown to exert suppressive capacity via IL-10 in this model of arthritis and in other models of autoimmunity (Brummel and Lenert, 2005, Evans et al., 2007, Tian et al., 2001, Yanaba et al., 2009).