Previous studies have revealed a role for LPA signaling in HSC activation (Yanase et al., 2000), and LPAR1 antagonism has been shown to reduce fibrosis in a rodent model of hepatocellular carcinoma and mouse model of centrilobular fibrosis (Bollong et al., 2017, Nakagawa et al., 2016). The gene discussed is LPAR1; the disease is hepatocellular carcinoma.