CEACAM5 and metastatic malignant neoplasm in the lymph nodes: The guidelines of ASCO, ESMO, or NCCN recommend different risk factors for stage II CRC among the parameters, such as vascular invasion, lymphatic invasion, T4, obstruction, perforation, < 12 LNs examined, poorly or undifferentiated histology, high serum CEA and others, but the evidence level of these factors is not high.28–30 Considering that lymph node metastasis is a well-established predictive marker for survival in stage III CRC patients, it is likely that high metastasis volume detected by OSNA test may predict pStage II patients’ survival as well.