On the other hand, ever-drinking was significantly associated with a decreased risk of all-cause and breast cancer-specific death among the patients with ER-/PR- cancer (all-cause death, HR = 0.49, p = 0.03; breast cancer-specific death, HR = 0.41, p = 0.01 in comparison to never-drinking). The gene discussed is ESR1; the disease is breast carcinoma.