IKZF2 and neoplasm: Consequently,ASCs not only increase the population of FOXP3+ Tregs,but also induce the expression of Helios in these cells.This transcription factor, along with FOXP3, can increasesuppressive activity of Tregs and since Helios+ cellsproduce less inflammatory cytokines than Helios- cells(33), the former cells probably show more suppressiveactivity in the tumor site.