CD4 and neoplasm: CD25- T cells are a subset of Tregs induced by tumorand involved in tumor-induced immunosuppression (24).Yang et al. (25) realized that a specific proportion ofintratumoral CD4+ T cells in non-Hodgkin lymphomapatients was CD4+CD25-FOXP3+ Tregs with the abilityof suppressing T cells proliferation.