The present research study provided for the first time,evidence that intrauterine exposure to hyperglycemiacauses hypomethylation of CDKN2A and CDKN2B inpancreatic islets derived from the offspring of GDM rats.This differential methylation was most notable in CpG8and CPG9 for CDKN2A and CDKN2B, respectively. Here, CDKN2B is linked to gestational diabetes.