The expressionof PTEN as a tumor suppressor, significantly increasedafter treatment with the combination of both compounds.We observed that the expression of B-RAF and RAF-1decreased following treatment with selective doses (ATO1 μM and THAL 60 μM for U937) and their combination(ATO 1 μM /THAL 60 μM). The gene discussed is PTEN; the disease is neoplasm.