In2010, Redondo-Muñoz et al. (28) and Goussetis andPlatanias (29) in two studies reported that ATO inducescell apoptosis in chronic lymphocytic leukemia (CLL)that involved upregulation of PTEN and inhibition of thePI3K/Akt/NF-κB as a survival pathway Goussetis andPlatanias (29) also stated that ATO induces upregulationof PTEN but downregulation of X-linked inhibitor ofapoptosis protein (XIAP). This evidence concerns the gene PTEN and B-cell chronic lymphocytic leukemia.