CD4 and myeloid sarcoma: Among them, T helper-17 (Th-17) plays a pivotal role in MS pathogenesis.Th-17 is a CD4+ T helper cell originated from Naïve CD4+ cells upon the expression and activation of interleukin-23 (IL-23),IL-6 and transforming growth factor-beta (TGF-β) (6-8).