Accumulating data show that down‐regulation of lncRNA NKILA or up‐regulation of XLOC_008466 and FAL1 is linked to lymph node metastasis and TNM stage,12, 13, 15 and lncRNA AFAP1‐AS1, linc00673 and PVT1 predict a poor prognosis in NSCLC.10, 16, 17 lncRNA DLEU2 is identified to have a differential expression in LAC,20 acute myeloid leukaemia21 and laryngeal carcinoma.22 Herein, we found that lncRNA DLEU2 expression levels were remarkably elevated in NSCLC tissue samples, but had no association with the clinicopathological parameters. This evidence concerns the gene AFAP1 and laryngeal carcinoma.