Mechanistically, lncRNA XLOC_008466 and linc00673 act by sponging miR‐874/‐150‐5p,15, 16 but lncRNA PVT1 reduces the proliferation of NSCLC by sponging miR‐195.17 Moreover, loss of lncRNA DLEU2 favours the proliferation by regulating miR‐15a/‐16‐1 in chronic lymphocytic leukaemia.25 Herein, lncRNA DLEU2 had the potential to bind with the Ago2‐miR‐30a‐5p complex and reduced the expression levels of miR‐30a‐5p, indicating that lncRNA DLEU2 might act as a sponge of miR‐30a‐5p in NSCLC cells. This evidence concerns the gene AGO2 and B-cell chronic lymphocytic leukemia.