SMAD4 and hepatocellular carcinoma: Moreover, ablation of USP10 by either shRNAs or USP10 inhibitor Spautin‐1 significantly suppresses the metastasis of HCC cells in vitro and/or in vivo, whereas the reconstitution of Smad4 was able to efficiently rescue this defect, indicating that targeting USP10 could be a novel therapeutic strategy of metastatic HCC displaying high level of Smad4.