Particularly, in HCC models, TGF‐β/Smad4 promotes invasion/metastasis by promoting ERK pathway‐mediated FGFR4 expression (Huang et al., 2018) or through lncRNA activated by TGF‐β (lncRNA‐ATB) by competitively binding the miR‐200 family and up‐regulating ZEB1/2 (Yuan et al., 2014). This evidence concerns the gene TGFB1 and hepatocellular carcinoma.