Although the two‐step mode of SC activation seems to prevail as the underlying mechanism of HF regeneration, there are examples that anagen initiation and HF regeneration can occur when Shh signaling is activated in the epithelial part of the HF during telogen,29, 30 suggesting that ectopic activation of Shh signaling in the bulge can substitute the signal required from the DP to activate the HG. Here, SHH is linked to hydrops fetalis.