Recently, Khan et al discussed a synaptic origin of the MFSD8‐associated retinal disease based on the observation that ERG abnormalities seen in the MFSD8‐patients reported are indicative of a post‐phototransduction abnormality and that murine MFSD8 localizes to the photoreceptor presynaptic terminals in the outer plexiform layer.2 The ocular phenotype in the patients studied suggests that, of all affected cell types, macular photoreceptors would be most sensitive to MFSD8 mutations, followed by the extramacular photoreceptors, with cortical neurons being the most resistant. This evidence concerns the gene MFSD8 and Abnormal retinal morphology.