NOS3 and myocardial infarction: Preclinical studies have successfully shown that PDE5Is can enhance this pathway in ischaemia–reperfusion injury and myocardial infarction (MI) by increasing levels of inducible and NOS3 activity in the heart (Das, Xi, & Kukreja, 2005), augmenting mitoKATP opening via PKG‐dependent mechanisms (Ockaili, Salloum et al., 2002) and delaying normalisation of intracellular acidosis (Inserte, Barba et al., 2011).