PDE5A and substance dependence: PDE5 activation has also been implicated in angiotensin II‐dependent hypertension (Ramseyer, Ortiz et al., 2016) and in experimental models, PDE5 inhibition has been demonstrated to reduce angiotensin II levels and restore the baroreflex in renovascular hypertension (Cavalcanti, Alves et al., 2016; Dias, Rodrigues et al., 2014).