In ALS, both peptides from UCHL1 were increased in CSF compared to control (UCHL1-LGF: ratio = 1.22, p = 0.005, UCHL1-LGV: ratio = 1.84, p = 0.002) and GPNMB levels were also increased in ALS compared to controls (ratio = 1.37, p = 0.020). This evidence concerns the gene UCHL1 and amyotrophic lateral sclerosis.