In this regard, it should be noted that the current study has focused on sporadic non-mutated SOD1 ALS cases; however, misfolded SOD-1 aggregates are generally present in sporadic non-SOD1 ALS patient’s glial and neuronal cells in the spinal cord (Forsberg et al. 2010, 2011, 2019). The gene discussed is SOD1; the disease is amyotrophic lateral sclerosis.