But, while this marker has been used to study mouse models of ALS (Genc et al. 2015; Gautam et al. 2016) and to investigate epidermal small-fiber neuropathy in ALS (Weis et al. 2011), we report the first use of peptide quantification in CSF to evaluate ALS levels of UCHL1. This evidence concerns the gene UCHL1 and amyotrophic lateral sclerosis.