ERBB2 and colorectal carcinoma: Of the 1490 CRC specimens assessed by IHC, 959 (64.4%), 410 (27.5%), 87 (5.8%), and 34 (2.3%) had HER2 scores of 0, 1+, 2+, and 3+, respectively, according to the criteria for gastroesophageal adenocarcinoma (Fig. 1a–d).