ERBB2 and neoplasm: To further explore the impact of HER2 on survival based on different scoring systems, we selected patients with stage II-III CRC who receive surgery as initial treatment; the results showed that gender, vascular invasion, perineural invasion, HER2 status, and tumor stage were associated with DFS, yet multivariate analysis showed only tumor stage was the independent prognostic factor according to the HERACLES criteria.