At 3 to 6 months, after a mean weight loss of approximately 20 kg and a decrease in BMI of approximately 6 kg/m2 (Table 1), S(I) improved significantly in obese participants with NFG (ratio of geometric means 2.48 [1.64, 3.74]; P = 0.0004), IFG (ratio of geometric means 2.52 [1.80, 3.53]; P < 0.0001) and T2DM (ratio of geometric means 2.43 [1.78, 3.33]; P < 0.0001) (Table 2, Fig. 1a). This evidence concerns the gene IFNG and type 2 diabetes mellitus.