While some studies have reported no statistically significant change in insulin secretion with medical weight loss in participants with NFG and IFG (6), we found that participants with severe obesity and NFG, IFG, or T2DM all had decreases in insulin secretion and achieved the same levels of insulin secretion 3 to 6 months after weight loss. This evidence concerns the gene INS and obesity due to melanocortin 4 receptor deficiency.