However, we identified no significant SNP-SNP interaction for neovascular AMD and PCV between the tagging SNPs in C5 and C3. Also, no gene-gene interaction was identified between C5 and C2-CFB-RDBP-SKIV2L, SERPING1, CETP, ABCG1, PGF, ANGPT2, CFH or HTRA1. Moreover, no gene-gender interaction was identified for C5 in AMD or PCV. Here, HTRA1 is linked to age-related macular degeneration.