The dimeric dipeptide mimetic of nerve growth factor loop 4, GK-2, administeredsubchronically and starting 6 and 24 h after surgery statisticallysignificantly restores the reduced proliferation of neuronal stem cells in thehippocampus and increases the proliferative activity in the striatum, accordingto the Ki67 marker, in an experimental ischemic stroke caused by transientocclusion of the middle cerebral artery. Here, MKI67 is linked to ischemic stroke.