We highlight DAPP1 (dual adaptor of phosphotyrosine and 3-phosphoinositides) as a recent large-scale CNV study of > 1600 individuals identified a paternally inherited duplication in two unrelated individuals with ASC that disrupts several exons of DAPP1 [96], and large duplications and deletions in the gene are reported in the DECHIPER database—the majority of which list autism, autistic behaviours, global developmental delay and/or intellectual disability as the associated phenotype [97]. The gene discussed is DAPP1; the disease is Intellectual disability.