The existing evidence for the association of IGHG1 with ASC, together with the observation that immune-related genes and pathways are some of the most common and highly replicated findings in ASC gene expression studies (discussed further below), lends further support to our identification of IGHG4 as an ASC-associated DE gene. The gene discussed is IGHG4; the disease is Tako-tsubo cardiomyopathy.