Compound K induces autophagy-mediated apoptosis through AMPK/mTOR and JNK pathways in human NSCLC A549 and H1975 cells [250], while it also induces autophagy and apoptosis through ROS and JNK pathways in human colorectal cancer HCT-116 cells [251]. This evidence concerns the gene MAPK8 and non-small cell lung carcinoma.