UA induces apoptosis and cell arrest through p21-mediated p53 activation in human colorectal cancer SW-480 and breast cancer MCF-7 cells [296, 297], and this p53 activation is through inhibiting negative regulators of p53, MDM2 and T-LAK cell-originated protein kinase (TOPK) [297]. The gene discussed is PBK; the disease is colorectal cancer.