It induces autophagy through 5′AMP-activated protein kinase (AMPK) activation, leading to Akt degradation, thus inhibiting cell proliferation and migration in human breast cancer MDA-MB-231 cells [21], while it inhibits cell growth partially through autophagy induction in human hepatocellular carcinoma HepG2 cells [29]. The gene discussed is AKT1; the disease is breast cancer.