It up-regulates plasminogen activator inhibitor-1 (PAI-1), a tumor suppressor that down-regulates urokinase-type plasminogen activator (uPA) and antagonizes uPA receptor to suppress metastasis in human hepatocellular carcinoma Bel-7402 and SMMC-7721 cells [143]. This evidence concerns the gene SERPINE1 and neoplasm.