Oridonin also inhibits cell proliferation through bone morphogenetic protein 7 (BMP7)/p38 MAPK/p53 pathway in human colorectal cancer HCT-116 and SW-620 cells [553, 576, 577], and induces apoptosis via hydrogen peroxide (H2O2) production and glutathione depletion in human colorectal cancer SW-1116 cells [578]. Here, TP53 is linked to colorectal cancer.