CASP3 and gastric cancer: Tanshinone IIA induces apoptosis through mitochondrial- and caspase-dependent pathways, which includes caspase-3, -9 and PARP activation, cytochrome c release, and increased ratio of Bax/Bcl-2 in human gastric cancer MKN45 and SGC-7901 cells, and tumor-bearing mice [518].