On the other hand, cucurbitacin E induces cell arrest and apoptosis via STAT3 inhibition in human breast cancer Bcap-37 and MDA-MB-231 cells [468], and cucurbitacin I can inhibit STAT3 pathway to suppress cancer stem cell properties in anaplastic thyroid cancer ATC–CD133+ cells [463]. The gene discussed is STAT3; the disease is thyroid gland undifferentiated (anaplastic) carcinoma.