On the other hand, tanshinone I induces apoptosis via Bcl-2 down-regulation in human gastric cancer BGC-823 and SGC-7901 cells [510], while cryptotanshinone induces apoptosis through mitochondrial-, cyclin- and caspase-dependent pathways in human NSCLC A549 and NCI-H460 cells [532], as well as via ER stress in human hepatocellular carcinoma HepG2 and breast cancer MCF-7 cells [533]. This evidence concerns the gene BCL2 and breast cancer.