ART inhibits angiogenesis through mitogen-activated protein kinase (MAPK) activation in osteosarcoma [204], whilst DHA exerts strong anti-angiogenic effect by repressing extracellular signal–regulated kinase (ERK) and NF-κB pathways in human umbilical vein endothelial cells (HUVECs) and pancreatic cancer, respectively [194, 195]. This evidence concerns the gene NFKB1 and familial pancreatic carcinoma.