Ginsenoside Rh2 induces cell death through p53 activation in human colorectal cancer HCT-116 and SW-480 cells [257], while ginsenoside Rg3 and compound K induces apoptosis and cell cycle arrest through p53/p21 up-regulation in human colorectal cancer HCT-116, SW-480 and HT-29, and gallbladder cancer NOZ and GBC-SD cells, respectively [244, 258]. The gene discussed is TP53; the disease is colorectal cancer.