As a CNV-driven ceRNA, CDKN2B has been reported to serve as a functional unit in the oncogenesis of malignant gliomas (Shete et al., 2009; Weller et al., 2009), its ceRNA pairs, CDK2 and RBL1, were also annotated in cell cycle and located in the downstream of the pathway (Figure 4C). This evidence concerns the gene RBL1 and malignant glioma.